Science & medicine

The Evidence Gap

How medical knowledge is made, and where it goes missing

by Priya Raghunathan (2) Read reviews

Four clinical questions, followed from the first small study to the guideline that changed practice — including everything that was never published.

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A guideline that tells a doctor what to do began, years earlier, as a question somebody found interesting. In between sit funding decisions, trial designs, results that were never written up, and reviews that quietly excluded the inconvenient studies.

Priya Raghunathan follows four clinical questions along that whole route, and pays particular attention to the parts that leave no public trace.

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4.5 from 2 reviews

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Dr S. Hammond September 19, 2025 Sample

Should be required reading

I teach evidence-based practice and I am putting this on the reading list. The chapter on unpublished trials is superb.

Alan Pryce October 30, 2025 Sample

Dense but rewarding

Not a light read. The index is excellent, which matters for a book you return to.

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